What is the ideal dose of Memantine in patients with renal impairment?

In patients with renal impairment, the dosing of Memantine must be carefully adjusted due to the drug’s renal clearance. Memantine is typically prescribed at a starting dose of 5mg daily, as this allows for titration based on tolerance and kidney function. For individuals with moderate to severe renal impairment, the maximum recommended dose is 10mg per day. By selecting 10mg as the appropriate dose in this context, it acknowledges the need to mitigate the risk of accumulation and potential toxicity, ensuring patient safety while still aiming for therapeutic efficacy.

In summary, the choice of 10mg represents an understanding of modifying medication doses in response to kidney function, which is critical in pharmacotherapy for patients with renal conditions.