What is the indication for alfacalcidol?

Alfacalcidol is a form of vitamin D that is specifically indicated for the prevention of vitamin D deficiency in patients with severe renal impairment or disease. In cases of renal dysfunction, the conversion of vitamin D to its active form, calcitriol, is impaired, leading to an increased risk of vitamin D deficiency. Alfacalcidol is more readily converted to active metabolites in the body, making it especially beneficial for patients who may have difficulty metabolizing standard vitamin D supplements due to kidney issues.

This action helps maintain calcium and phosphate balance, which are critical for maintaining bone health and preventing the complications associated with renal disease, such as secondary hyperparathyroidism and bone disorders. The other choices do not accurately reflect the specific therapeutic role of alfacalcidol in managing vitamin D deficiency in patients with renal impairment.