What is the primary function of NMDA antagonists in Alzheimer's treatment?

The primary function of NMDA antagonists in Alzheimer's treatment is to regulate glutamate, which is crucial for learning and memory processes. In Alzheimer's disease, there is often an overactivation of NMDA receptors due to excessive glutamate, which can lead to neurotoxicity and contribute to cognitive decline. NMDA antagonists work by blocking these receptors, thereby helping to stabilize glutamate levels in the brain. This action not only protects neurons from excessive excitatory signaling but also can help improve cognitive functions, making it a significant mechanism in the management of Alzheimer's disease.

By decreasing glutamate's harmful excitatory effects, NMDA antagonists can potentially improve cognitive symptoms and slow the progression of memory loss associated with the disease. This focus on glutamate regulation aligns with current therapeutic strategies aimed at addressing both the symptoms and underlying neuronal damage in Alzheimer's disease.