What is the role of SGLT2 inhibitors in heart failure management?

SGLT2 inhibitors play an important role in heart failure management primarily by preventing fluid overload. These medications work by inhibiting the sodium-glucose co-transporter 2 in the kidneys, leading to increased glucose excretion and diuresis. This diuretic effect helps to reduce blood volume and relieve symptoms of fluid overload, such as edema and dyspnea, which are common in heart failure patients.

By decreasing the amount of fluid in the circulation, SGLT2 inhibitors can improve heart function and reduce the burden on the heart. Their impact on fluid balance is particularly beneficial in heart failure management, where managing fluid status is crucial to improving patient outcomes and quality of life.

While SGLT2 inhibitors also have beneficial effects on blood sugar control, their primary role in this context is centered around managing fluid overload. Other options do not address the specific mechanism of action and therapeutic benefits of SGLT2 inhibitors within the context of heart failure treatment.