Which beta blockers are known to reduce peripheral coldness due to their intrinsic sympathomimetic activity?

The choice that accurately identifies beta blockers known to reduce peripheral coldness due to their intrinsic sympathomimetic activity is indeed the one that includes Celiprolol, Pindolol, and Acebutolol. These beta blockers exhibit unique properties that set them apart from others in their class.

Intrinsic sympathomimetic activity (ISA) refers to the partial agonist activity that some beta blockers possess. This means that while they block beta-adrenergic receptors, they also stimulate them to a lesser degree. This dual action can lead to a more balanced cardiovascular response, often resulting in less peripheral vasoconstriction compared to beta blockers without ISA. As a result, patients taking beta blockers with ISA may experience less coldness in their extremities, as the medication helps to maintain better peripheral blood flow.

In contrast, the other beta blockers mentioned in the other choices lack this ISA feature. For instance, Metoprolol, Atenolol, and Bisoprolol are primarily selective beta-1 blockers without significant sympathomimetic activity, which can lead to increased peripheral vasoconstriction and potentially colder extremities. The same applies to Propranolol, Carvedilol, and Nebivolol, all of