Which diabetes drug is known to cause weight gain?

Sulfonylureas are known to cause weight gain in patients with diabetes. These medications stimulate the pancreas to produce more insulin, which can lead to increased calorie intake and potential weight gain. Additionally, by increasing insulin levels, sulfonylureas may decrease the body's ability to utilize fat for energy, further contributing to weight gain.

In contrast, GLP-1 agonists often lead to weight loss, as they help to reduce appetite and slow gastric emptying. Metformin is typically weight-neutral or may even promote slight weight loss due to its mechanism of decreasing glucose production by the liver and improving insulin sensitivity. SGLT2 inhibitors are also associated with weight loss by promoting the excretion of glucose through urine, which reduces calorie absorption.

Understanding these differences in how each medication affects body weight is crucial for managing diabetes effectively, particularly when considering the overall health and metabolic profile of patients.