Which factors can impact anticoagulation treatment?

Anticoagulation treatment can be significantly influenced by various physiological and pathological factors. Renal impairment is particularly critical because the kidneys are responsible for the clearance of many anticoagulants, especially those that are renally excreted. When renal function is compromised, there may be an increased risk of drug accumulation, leading to a higher likelihood of bleeding complications. On the other hand, certain types of cancer can also affect the coagulation system, increasing the risk for thrombosis or necessitating adjustments in anticoagulant dosage due to altered metabolism or drug interactions.

These factors are essential in determining the appropriate anticoagulation therapy and monitoring parameters, as improper consideration may lead to therapeutic failure or adverse events.