Which of the following drugs is known to potentially cause Stevens-Johnson syndrome (SJS)?

Carbamazepine is known to potentially cause Stevens-Johnson syndrome (SJS), which is a severe and potentially life-threatening skin reaction characterized by the detachment of the epidermis and mucous membrane involvement. The exact mechanism of how carbamazepine induces SJS is not entirely understood, but it is believed to involve an immune-mediated process.

Carbamazepine is an anticonvulsant and mood-stabilizing medication often used to treat epilepsy and bipolar disorder. It has been associated with SJS particularly in certain populations, such as those with specific genetic markers like the HLA-B*1502 allele, which is more prevalent in certain ethnic groups.

While other drugs listed, such as ibuprofen, lisinopril, and amoxicillin, can cause other types of adverse reactions, they are not as strongly linked to the development of SJS compared to carbamazepine. Understanding the risks associated with medications is crucial for making informed decisions on treatment options and monitoring patients for adverse effects.