Which of the following is a side effect associated with SGLT2 inhibitors?

SGLT2 inhibitors are a class of medications used in the management of type 2 diabetes by reducing glucose reabsorption in the kidneys, leading to increased glucose excretion in urine. One of the serious but rare side effects associated with SGLT2 inhibitors is Fournier gangrene, which is a necrotizing fasciitis affecting the genital region. This condition is potentially life-threatening and requires immediate medical attention.

The occurrence of Fournier gangrene has been noted in clinical studies and case reports, prompting healthcare providers to be vigilant in monitoring for signs of this infection in patients taking SGLT2 inhibitors. The pathophysiology appears to involve both the diabetes-related susceptibility to infections and the changes in the urinary microbiome induced by the medication.

The other options do not align with the common or notable side effects of SGLT2 inhibitors. Hypertension is not typically associated with these drugs; instead, they may have a neutral or even beneficial effect on blood pressure. Bradycardia is also uncommon, and weight gain is not a typical outcome since SGLT2 inhibitors are associated with weight loss in many patients. Hence, Fournier gangrene stands out as a distinct and significant side effect related to the use of SGLT