Which of the following is a caution when prescribing donepezil?

Donepezil is an acetylcholinesterase inhibitor commonly used to treat symptoms of Alzheimer's disease. One of the known cautions when prescribing donepezil is the susceptibility to peptic ulcers. This is particularly relevant because donepezil can increase gastric secretions due to its cholinergic effects. The increase in gastric acid can exacerbate or contribute to the formation of peptic ulcers in susceptible patients. Therefore, it is essential for healthcare providers to consider a patient’s history regarding gastrointestinal issues before prescribing donepezil, as it may lead to complications such as ulcer formation or worsening of existing ulcers.

The other options present different health concerns that are not primarily associated with donepezil. While allergic reactions may occur, they are not a specific caution linked to the routine use of this medication. Similarly, risks associated with diabetes and severe hypertension are not directly correlated with donepezil usage, making them less relevant as cautionary points in this context. Hence, susceptibility to peptic ulcers stands out as a key consideration when prescribing donepezil.