Which of the following is a potential side effect of corticosteroids?

Weight gain is a well-documented potential side effect of corticosteroids. These medications can cause changes in body fat distribution and increase appetite, leading to an overall increase in body weight. Corticosteroids influence the metabolism of carbohydrates, proteins, and fats, often resulting in increased fat storage and water retention. Additionally, they can affect the body’s hormonal balance, which may further contribute to weight gain.

In contrast, increased bone density, improved metabolism, and decreased appetite are not typical side effects associated with corticosteroid use. In fact, chronic use of corticosteroids is known to decrease bone density, which raises the risk of osteoporosis and fractures. Additionally, corticosteroids generally do not improve metabolism; rather, they can lead to metabolic changes that unfavorably affect weight. Lastly, these medications may actually increase appetite rather than decrease it, making weight gain a more likely outcome.