Which of the following medications is frequently associated with inducing Parkinsonism?

Metoclopramide is frequently associated with inducing Parkinsonism due to its mechanism of action as a dopamine antagonist. It primarily works by blocking dopamine receptors in the brain, particularly the D2 receptors. This action can disrupt the balance of neurotransmitters in the central nervous system, leading to symptoms similar to those seen in Parkinson's disease, such as muscle rigidity, tremors, and bradykinesia.

In contrast, the other medications listed have different effects and are not commonly linked to the induction of Parkinsonism. Sertraline, an antidepressant, primarily affects serotonin levels without significant dopamine antagonist properties. Alprazolam, a benzodiazepine, functions mainly as a central nervous system depressant and does not interfere with dopamine pathways. Levothyroxine, a thyroid hormone replacement, does not have a direct impact on neurotransmitter systems related to Parkinson's disease.