Which of the following statements about long-term PPI use is true?

Long-term use of proton pump inhibitors (PPIs) is associated with several physiological impacts, one of which is the potential effect on calcium absorption. The correct choice highlights that PPI use may lead to lower calcium absorption and is supported by evidence indicating that reduced gastric acidity from PPIs can impair the solubility of calcium supplements or calcium-rich foods, ultimately affecting calcium bioavailability.

This reduced absorption can be especially significant in individuals who are at risk for osteoporosis or fractures, as adequate calcium levels are crucial for maintaining bone health. Research has shown a correlation between long-term PPI use and an increased risk of fractures, further emphasizing the importance of monitoring calcium levels in patients who are on these medications for extended periods.

While other choices may address important aspects of PPIs, they do not reflect the well-documented consequences of long-term PPI therapy on nutrient absorption, particularly concerning calcium. This understanding is essential for healthcare providers to consider when evaluating the risks versus benefits of prolonged PPI use in their patients.